John GARCIA National University of Colombia, Bogotá UNAL Escuela
What Is The Purpose Of The Plakophilin Gene. The pkp2 gene provides instructions for making a protein called plakophilin 2. Web plakophilin proteins contain numerous armadillo repeats, localize to cell desmosomes and nuclei, and participate in linking cadherins to intermediate filaments in the cytoskeleton.
Web the plakophilin gene is one of the important proteins to make up structures called desmosomes (medlineplus, 2020). How would mutations in the plakophilin gene disrupt cell to cell interactions? This protein is used to make desmosomes , a cell junction. You'll get a detailed solution from a subject matter expert that helps you learn core concepts. (1998) mapped the pkp2 gene to 12p13. Further analysis by bonne et al. This protein may be involved in molecular recruitment and stabilization. The results of our study verify the importance of this gene in the origin of arvc in that we identified. Web national center for biotechnology information This protein is found primarily in cells of the myocardium, which is the muscular wall of the heart.
Web plakophilins are members of the p120ctn arm repeat subfamily. You'll get a detailed solution from a subject matter expert that helps you learn core concepts. This protein may be involved in molecular recruitment and stabilization. Desmosomes help create cell connection resulting in strength in the myocardium, so desmosomes are important for the functionality of the. The genetic architecture of plakophilin 2 ( pkp2) cardiomyopathy can inform our understanding of its variant pathogenicity and protein function. Web by fluorescence in situ hybridization and analysis of a somatic cell hybrid mapping panel, bonne et al. This protein is used to make desmosomes , a cell junction. Web plakophilins are members of the p120ctn arm repeat subfamily. Web the pkp2 gene provides instructions for making a protein called plakophilin 2. Within these cells, plakophilin 2 is one of several proteins that make up structures called. Web plakophilin proteins contain numerous armadillo repeats, localize to cell desmosomes and nuclei, and participate in linking cadherins to intermediate filaments in the cytoskeleton.
