Why model? (Causal inference What if, Chapter 11) Speaker Deck
What Is An Estimand. It defines in detail what needs to be estimated to address a specific scientific question of interest. Web an estimand is a quantity that is to be estimated in a statistical analysis.
Why model? (Causal inference What if, Chapter 11) Speaker Deck
Web in general terms, an estimand is a precise description of the quantity one tries to estimate, reflecting a particular clinical question underlying a clinical trial. A similar degree of care should be given to defining the thing we are estimating. Web an estimand is a way to explicitly state how intercurrent events will be dealt with and ensure the objective of the trial, the design, data collection, and analyses are consistent with this approach. • population of interest • endpoint of interest • measure of intervention effect The term is used to more clearly distinguish the target of inference from the method used to obtain an approximation of this target (i.e., the estimator) and the specific value obtained from a given method and dataset (i.e., the estimate). It defines in detail what needs to be estimated to address a specific scientific question of interest. More specifically, it summarizes what the outcomes would be in “the same patients under different treatment conditions being compared.” Web what is an estimand? Much attention is already placed on how to do estimation; Web the estimand is the target quantity—the purpose of the statistical analysis.
Web estimand description (including endpoint) immunogenicity: A similar degree of care should be given to defining the thing we are estimating. Much attention is already placed on how to do estimation; Web an estimand is a quantity that is to be estimated in a statistical analysis. Web estimand description (including endpoint) immunogenicity: Web the estimand is the target quantity—the purpose of the statistical analysis. According to the ich report 1, an estimand is a description of the treatment effect associated with a clinical trial objective. Web an estimand is a way to explicitly state how intercurrent events will be dealt with and ensure the objective of the trial, the design, data collection, and analyses are consistent with this approach. To that effect, the ich e9(r1) guideline emphasizes the importance of defining the estimand attributes: The term is used to more clearly distinguish the target of inference from the method used to obtain an approximation of this target (i.e., the estimator) and the specific value obtained from a given method and dataset (i.e., the estimate). • population of interest • endpoint of interest • measure of intervention effect
